Comparative lipid profile study between ischemic and hemorrhagic stroke

To determine the frequency of dyslipidemias in patients with stroke and to compare the lipid levels in ischemic and hemorrhagic stroke patients. Patients with diagnosis of stroke comprising 50 consecutive patients each of ischaemic and haemorrhagic strokes were included in the study while patients on lipid lowering therapy were excluded from study. To determine the subtype of stroke, clinical examination followed by CT scan of brain was done. A serum sample after 8 hours of overnight fasting was taken on the next day of admission for both groups of patients. Total serum cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol and HDL-cholesterol was determined, using enzymatic colorimetric method. SPSS software was used for calculation of % R of 95% confidence interval (CI). It was noted in our study that fasting serum lipid profile analysis of 50 ischemic stroke patients revealed raised serum total cholesterol in 21 patients with mean serum cholesterol of 190±35mg/dl where as only 5 patients among hemorrhagic CVA showing raised serum cholesterol with overall mean of 151±29mg/dl. Serum HDL was found to be low in 16 patients i.e. 32% of Ischemic stroke with mean value of 42.4±6mg/dl whereas only 6% of Hemorrhagic stroke patients showing low serum HDL with mean value of 45.4±5mg/dl. Abnormal serum triglyceride level was found to be distributed similarly in Ischemic & Hemorrhagic stroke with mean value of 137±30mg/dl & 125±30mg/dl respectively. High serum LDL was found in 6% & 4% of ischemic & hemorrhagic stroke with mean value of 102±21mg/dl & 93±17mg/dl respectively. Hypercholesterolemia and low HDL-cholesterol was seen significantly more in ischemic CVA group. __________________________________________________________________________________________